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Jinan  Jia  Ge  Biological  Technology  Co., Ltd.
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Active Pharmaceutical Ingredients Aarticaine HCl CAS 23964-57-0

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Active Pharmaceutical Ingredients Aarticaine HCl CAS 23964-57-0

Brand Name : JNJG
Model Number : 23964-57-0
Certification : iso9001
Place of Origin : china
MOQ : Negotiable
Price : negotiation
Payment Terms : Western Union, L/C, D/P, MoneyGram
Supply Ability : 5000kg/year
Delivery Time : 3-5 work days
Packaging Details : 5g/foil bag
CAS : 23964-57-0
MF : C18h29cln2o
MW : 320.839
Assay : 99.5%
Appearance : White powder
Usage : Anesthetic;Na+ channel inhibitor
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Aarticaine HCl
CAS 23964-57-0
Articaine hydrochloride , its CAS NO. is 23964-57-0, the synonyms are 2-Thiophenecarboxylic acid,
4-methyl-3-((1-oxo-2-(propylamino)propyl)amino)-, methyl ester, monohydrochloride ; 4-Methyl-3-
(2-(propylamino)propionamido)-2-thiophenecarboxylic acid methyl ester HCl ; Articaine HCl ; Methyl
4-methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylate, monohydrochloride ; Septanest ; Septocaine .
Articaine is a dental local anesthetic. It is the most widely used local anesthetic in a number of European countries and is available in many countries around the world.
Structure and metabolism: The amide structure of articaine is similar to that of other local anesthetics, but its molecular structure differs through the presence of a thiophene ring instead of a benzene ring. Articaine is exceptional because it contains an additional ester group that is metabolized by esterases in blood and tissue. The elimination of articaine is exponential with a half-life of 20 minutes. Since articaine is hydrolized very quickly in the blood, the risk of systemic intoxication seems to be lower than with other anesthetics, especially if repeated injection is performed.
Applications:
Articaine is a local anaesthetic that has been approved overseas for several years. Like other amide anaesthetics, articaine blocks nerve conduction when it is infiltrated around a nerve. This action is prolonged by combining the drug with a vasoconstrictor
Clinical use:
(1) Articaine is used for pain control. Like other local anesthetic drugs, articaine causes a transient
and completely reversible state of anesthesia (loss of sensation) during (dental) procedures.
(2) In dentistry, articaine is used both for infiltration and block injections, with the block technique
yielding the greatest duration of anesthesia.
(3) In people with hypokalemic sensory overstimulation, lidocaine is not very effective, but articaine
works well.

Articaine is a dental amide-type local anesthetic.Articaine is used for pain control. Like other local anesthetic drugs, articaine causes a transient and completely reversible state of anesthesia (loss of sensation) during (dental) procedures.

In dentistry, articaine is used both for infiltration and block injections, with the block technique yielding the greatest duration of anesthesia.In people with hypokalemic sensory overstimulation, lidocaine is not very effective, but articaine works well.

Studies comparing lidocaine and articaine found that articaine is more effective than lidocaine in anaesthetising the posterior first molar region.Articaine has been found to be 3.81 times more likely than lidocaine to produce successful anaesthesia when used for infiltration injections. However, there is no evidence to support the use of articaine over lidocaine for inferior alveolar nerve blocks.Furthermore, articaine has been demonstrated to be superior to lidocaine for use of supplementary infiltration following persistent pain despite a successful inferior dental nerve block with lidocaine.

Active Pharmaceutical Ingredients Aarticaine HCl
Product NameAarticaine HCl Powder
CAS Registry Number23964-57-0
EINECS245-957-7
Molecular FormulaC13H21ClN2O3S
Molecular Weight320.84
Purity99%
GradePharmaceutical Grade
AppearanceWhite cystalline powder

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