Articaine hydrochloride , its CAS NO. is 23964-57-0, the synonyms
are 2-Thiophenecarboxylic acid,
4-methyl-3-((1-oxo-2-(propylamino)propyl)amino)-, methyl ester,
monohydrochloride ; 4-Methyl-3-
(2-(propylamino)propionamido)-2-thiophenecarboxylic acid methyl
ester HCl ; Articaine HCl ; Methyl
monohydrochloride ; Septanest ; Septocaine .
Articaine is a dental local anesthetic. It is the most widely used
local anesthetic in a number of European countries and is available
in many countries around the world.
Structure and metabolism: The amide structure of articaine is
similar to that of other local anesthetics, but its molecular
structure differs through the presence of a thiophene ring instead
of a benzene ring. Articaine is exceptional because it contains an
additional ester group that is metabolized by esterases in blood
and tissue. The elimination of articaine is exponential with a
half-life of 20 minutes. Since articaine is hydrolized very quickly
in the blood, the risk of systemic intoxication seems to be lower
than with other anesthetics, especially if repeated injection is
Articaine is a local anaesthetic that has been approved overseas
for several years. Like other amide anaesthetics, articaine blocks
nerve conduction when it is infiltrated around a nerve. This action
is prolonged by combining the drug with a vasoconstrictor
(1) Articaine is used for pain control. Like other local anesthetic
drugs, articaine causes a transient
and completely reversible state of anesthesia (loss of sensation)
during (dental) procedures.
(2) In dentistry, articaine is used both for infiltration and block
injections, with the block technique
yielding the greatest duration of anesthesia.
(3) In people with hypokalemic sensory overstimulation, lidocaine
is not very effective, but articaine
Articaine is a dental amide-type local anesthetic.Articaine is used
for pain control. Like other local anesthetic drugs, articaine
causes a transient and completely reversible state of anesthesia
(loss of sensation) during (dental) procedures.
In dentistry, articaine is used both for infiltration and block
injections, with the block technique yielding the greatest duration
of anesthesia.In people with hypokalemic sensory overstimulation,
lidocaine is not very effective, but articaine works well.
Studies comparing lidocaine and articaine found that articaine is
more effective than lidocaine in anaesthetising the posterior first
molar region.Articaine has been found to be 3.81 times more likely
than lidocaine to produce successful anaesthesia when used for
infiltration injections. However, there is no evidence to support
the use of articaine over lidocaine for inferior alveolar nerve
blocks.Furthermore, articaine has been demonstrated to be superior
to lidocaine for use of supplementary infiltration following
persistent pain despite a successful inferior dental nerve block
Active Pharmaceutical Ingredients Aarticaine HCl
|Product Name||Aarticaine HCl Powder|
|CAS Registry Number||23964-57-0|
|Appearance||White cystalline powder|
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